N-phenyl-2-cyano-3-hydroxycrotonamide derivatives and their...

Details N-phenyl-2-cyano-3-hydroxycrotonamide derivatives and their... N-phenyl-2-cyano-3-hydroxycrotonamide derivatives and their...

C - Chemistry, Metallurgy

07

C

C07C 255/44 (2006.01) A61K 31/275 (2006.01) C07C 255/23 (2006.01) C07C 255/60 (2006.01) C07C 323/63 (2006.01)

Patent

CA 2081173

HOE 91/F 332 Abstract: N-Phenyl-2-cyano-3-hydroxycrotonamide derivatives and their use as pharmaceuticals having an immunomodulatory property. The use of N-phenyl-2-cyano-3-hydroxycrotonamide derivatives of the formula I Image (I) in which R1 is a hydrogen atom or (C1-C4)-alkyl, R2 is CN, CX3, WCX3, W(CH2)nCX3, NO2, (CH2)nCX3, or halogen, in which X is halogen, W is an oxygen or sulfur atom and n is an integer from 1 to 3, R3 is (C1-C4)-alkyl, (C3-C6)-cyclo- alkyl, CN or -CO-R4, in which R4 is (C1-C4)-alkyl or (C3-C6)-cycloalkyl, and/or their physiologically tolerable salts, for the treatment of rheumatic diseases, auto- immune diseases, and of rejection reactions of the organ recipient to the transplanted organ, is described.

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