N-phenyl-2-pyrimidine-amine derivatives

Details N-phenyl-2-pyrimidine-amine derivatives N-phenyl-2-pyrimidine-amine derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01)

Patent

CA 2737565

The present invention relates to a process for the preparation of a compound of formula IV (see formula IV) wherein R1, R2, R4 and R5 are independently as defined in claim 1; R3 is (4-methyl- piperazinyl)-methyl, R6' is 4-(3-pyridyl)-2-pyrimidinamino, R7' is methyl and R8' is hydrogen, or a pharmaceutically acceptable salt or crystal form thereof, by reacting a compound of formula I (see formula I) wherein R1 to R5 are as defined above, R6 is - NHC(NH)NH2, R7 is methyl and R8 is hydrogen; with a compound of formula VI (see formula VI) wherein R10 is 3-pyridyl and R11 is hydrogen or lower alkyl.

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