N-phenyl-(2r,5s)dimethylpiperazine derivative

Details N-phenyl-(2r,5s)dimethylpiperazine derivative N-phenyl-(2r,5s)dimethylpiperazine derivative

C - Chemistry, Metallurgy

07

D

C07D 241/04 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/498 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61K 31/5377 (2006.01) A61P 5/28 (2006.01) A61P 13/08 (2006.01) A61P 17/08 (2006.01) A61P 17/14 (2006.01) A61P 35/00 (2006.01) C07D 213/75 (2006.01) C07D 213/84 (2006.01) C07D 213/85 (2006.01) C07D 239/42 (2006.01) C07D 295/215 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2492138

The present invention relates to a novel N-phenyl--(2R,5S)dimethylpiperazine derivatives useful as antiandrogenic agent which exhibits a sufficient prostate gland reducing effect as compared with conventional compounds and are excellent in oral activity. The compound of the present application is useful in preventing or treating prostate cancer, benign prostatic hyperplasia, and the like. The present invention also provides a novel intermediate useful in producing the compound of the present invention.

L'invention concerne un nouveau dérivé de N-phényl-(2R, 5S)diméthylpipérazine utile comme médicament anti-androgène, supérieur au composé existant en ce qu'il permet de réduire suffisamment la taille de la prostate et possède une excellente activité par voie orale. Ce composé est utile pour prévenir ou traiter le cancer de la prostate, une augmentation du volume de la prostate, etc.. L'invention concerne aussi un nouveau produit intermédiaire utile dans la production du composé décrit.

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