N-phenyl-imidazo[1,2-a]pyridine-2-carboxamide compounds,...

Details N-phenyl-imidazo[1,2-a]pyridine-2-carboxamide compounds,... N-phenyl-imidazo[1,2-a]pyridine-2-carboxamide compounds,...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 19/10 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 213/70 (2006.01) C07D 213/71 (2006.01) C07D 213/74 (2006.01) C07D 233/64 (2006.01)

Patent

CA 2710811

The invention relates to compounds of the formula (I) in which: X is an optionally substituted phenyl group; R1 is a hydrogen atom, a halogen atom, a (C1-C6)alkoxy group, a (C1-C6)alkyl group, amino, an NRcRd group; R2 is a NRcRd group, a -N=CH-NraRb group, nitro, hydroxyiminoalkyl, alkoxyiminoalkyl, a (C1-C6)alkylthio group, a (C1-C6)alkylsulfinyl group, a (C1-C6)alkylsulfonyl group, a -SO2-NR5R6 group, a ((C1-C6)alkyl)3)silylethynyl group; R3 is a hydrogen atom, a (C1-C6)alkyl group, a (C1-C6)alkoxy group or a halogen atom; R4 is a hydrogen atom, a (C1-C4)alkyl group, a (C1-C4)alkoxy group or a fluorine atom; wherein said compounds are in the state of a base or an addition salt to an acid. The invention also relates to the therapeutic use thereof.

Composés de formule (I) dans laquelle X représente un groupe phényle éventuellement substitué; R1 représente un atome d'hydrogène, un atome d'halogène, un groupe (C1-C6)alcoxy, un groupe (C1- C6)alkyle, un amino, un groupe NRcRd; R2 représente un groupe NRcRd, un groupe -N=CH-NRaRb, nitro, hydroxyiminoalkyle, alcoxyiminoalkyle, un groupe (C1-C6)alkylthio, un groupe (C1-C6)alkylsulfinyle, un groupe (C1-C6)alkylsulfonyle, un groupe -S02- NR5R6, un groupe ((C1-C6)alkyl)3)silyléthynyle; R3 représente un atome d'hydrogène, un groupe (C1-C6)alkyle, un groupe (C1- C6)alcoxy ou un atome d'halogène, R4 représente un atome d'hydrogène, un groupe (C1-C4)alkyle, un groupe (C1-C4)alcoxy ou un atome de fluor, à l'état de base ou de sel d'addition à un acide. Utilisation en thérapeutique.

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