N'-(phenyl)-n-(morpholin-4-yl-pyridin-2-yl)-pyrimidine-2,4-d...

Details N'-(phenyl)-n-(morpholin-4-yl-pyridin-2-yl)-pyrimidine-2,4-d... N'-(phenyl)-n-(morpholin-4-yl-pyridin-2-yl)-pyrimidine-2,4-d...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2687943

The invention concerns pyrimidine com pounds of Formula (I), or a pharmaceutically acceptable salt thereof where A1, A2, A3, R1, n, R2, R3, and R4 are as defined in the description. The present invention also relates to pr ocesses for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to th e inhibition of EphB4 kinases.

La présente invention concerne les composés pyrimidines de formule I, ou un sel pharmaceutiquement acceptable de ceux-ci où A1, A2, A3, R1, n, R2, R3, et R4sont définis dans la description. La présente invention concerne également des procédés pour la préparation de ces composés, des compositions pharmaceutiques les contenant et leur utilisation dans la fabrication d'un médicament pour utilisation comme agent antiprolifératif dans la prévention ou le traitement de tumeurs ou d'autres états prolifératifs qui sont sensibles à l'inhibition de EphB4 kinases.

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