C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/04 (2006.01) A61K 31/495 (2006.01) A61P 25/18 (2006.01) A61P 25/28 (2006.01) A61P 25/30 (2006.01) C07D 295/096 (2006.01) C07D 317/06 (2006.01)
Patent
CA 2759482
The present invention relates to N-phenyl-(piperazinyl or homopiperazinyl)- benzenesulfonamide or benzenesulfonyl-phenyl-(piperazine or homopiperazine) compounds,pharmaceutical compositions containing them, and their use in therapy. The compounds possess valuable therapeutic properties and are particularly suitable for treating diseases that respond to modulation of the serotonin 5-HT6 receptor. wherein X is a bond or a group N-R4; R1 is hydrogen or methyl; R2 is hydrogen or methyl; R3 is hydrogen, C1-C3 alkyl, fluorine, C1-C2 alkoxy or fluorinated C1-C2 alkoxy; R4 is hydrogen, C1-C4 alkyl, C3-C4 cycloalkyl, or C3-C4 cycloalkyl-CH2-; R5 is hydrogen, fluorine, chlorine, C1-C2 alkyl, fluorinated C1-C2 alkyl, C1-C2 alkoxy or fluorinated C1-C2 alkoxy; R6 is hydrogen, fluorine or chlorine; and n is 1 or 2.
L'invention porte sur des composés N-phényl-(pipérazinyl ou homopipérazinyl)- benzènesulfonamide ou benzènesulfonyl-phényl-(pipérazine ou homopipérazine), sur des compositions pharmaceutiques les contenant, et sur leurs utilisations thérapeutiques. Ces composés aux propriétés thérapeutiques appréciables sont particulièrement adaptés au traitement de troubles répondant à la modulation du récepteur 5-HT6 de la sérotonine. Dans leur formule: X est une liaison ou un groupe N-R4; R1 est hydrogène ou méthyle; R2 est hydrogène ou méthyle; R3 est hydrogène, C1-C3 alkyle, fluor, C1-C2 alkoxy ou C1-C2 alkoxy fluoré; R4 est hydrogène, C1-C4 alkyle, C3-C4 cycloalkyle, ou C3-C4 cycloalkyl-CH2-; R5 est hydrogène, fluor, chlore, C1-C2 alkyle, C1-C2 alkyle fluoré, C1-C2 alkoxy ou C1-C2 alkoxy fluoré; R6 est hydrogène, fluor ou chlore; et n est 1 ou 2.
Backfisch Gisela
Bespalov Anton
Delzer Juergen
Drescher Karla
Haupt Andreas
Abbott Gmbh & Co. Kg
Torys Llp
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