N-(phosphonoacetyl)-l-aspartic acid compounds and methods...

Details N-(phosphonoacetyl)-l-aspartic acid compounds and methods... N-(phosphonoacetyl)-l-aspartic acid compounds and methods...

C - Chemistry, Metallurgy

07

F

260/501.5, 260/4

C07F 9/38 (2006.01) A61K 31/66 (2006.01) C07F 9/40 (2006.01)

Patent

CA 1110266

Abstract of the Disclosure N-(Phosphonoacetyl)-L-aspartic acid (PALA) compounds, especially novel PALA compounds, and methods for their preparation in large amounts are disclosed, These methods include preparation of certain PALA compounds such are PALA dibenzyl ester, disodium PALA, and the cyclohexylamine salt of dibenzyl PALA. The compounds of this invention possess antitumor activity in vivo or are intermediates for the production of active antitumor PALA compounds.

316224

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