A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/445 (2006.01) A61K 31/454 (2006.01) A61K 31/5377 (2006.01) A61P 3/04 (2006.01) C07D 211/26 (2006.01) C07D 211/34 (2006.01) C07D 413/06 (2006.01)
Patent
CA 2725355
Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity, are disclosed Specifically, a series of compounds which are N-piperidinyl acetamide derivatives as shown in formula (1) are disclosed as calcium ion channel activating modulators Compositions comprising these compounds and the use of these compounds in the treatment or prevention of conditions such as obesity are also disclosed.
L'invention concerne des méthodes et des composés efficaces pour améliorer des états caractérisés par une activité indésirable des canaux calciques, en particulier une activité des canaux calciques de type T. De manière plus spécifique, l'invention concerne une série de composés qui sont des dérivés de N-piperidinyl acétamide représentés par la formule (1) et utilisés comme modulateurs de l'activité des canaux ioniques calciques. L'invention concerne des compositions comprenant ces composés et l'utilisation de ces composés pour traiter ou prévenir l'obésité.
Chakka Nagasree
Ding Yanbing
Grimwood Mike
Kaul Ramesh
Pajouhesh Hassan
Fetherstonhaugh & Co.
Zalicus Pharmaceuticals Ltd.
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