N-(pyridinylamino)isoindolines and related compounds

Details N-(pyridinylamino)isoindolines and related compounds N-(pyridinylamino)isoindolines and related compounds

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/40 (2006.01) C07D 213/77 (2006.01) C07D 263/14 (2006.01) C07D 401/14 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2276203

Novel N-(pyridinylamino)isoindolines of formula (I) and related compounds, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the N- (pyridinylamino)isoindolines and related compounds, the intermediates or compositions thereof are disclosed. Formula (I) R is hydrogen, a group of the formula R2O- wherein R2 is hydrogen, loweralkyl, benzyl, a group of the formula (R3)3Si- wherein R3 is loweralkyl, or a group of the formula R4R5NCO- wherein R4 and R5 are independently hydrogen, loweralkyl or benzyl; R4 and R5 taken together with the nitrogen atom to which they are attached form a group of formula (a) or a group of the formula (b); R1 is hydrogen or loweralkyl; X is hydrogen, loweralkyl, halogen, hydroxy loweralkoxy, or trifluoromethyl; Y is hydrogen, loweralkyl, halogen, hydroxy, loweralkoxy, or trifuoromethyl; m is 1 or 2; n is 1, 2, or 3; p is 1 or 2; the optical isomers thereof; or the pharmaceutically acceptable salts thereof.

L'invention porte sur de nouvelles N-(pyridinylamino)isoindolines et des composés associés, sur des intermédiaires, sur leurs procédés de préparation et sur des méthodes recourant aux N-(pyridinylamino)isoindolines pour atténuer les dysfonctionnements de la mémoire et traiter les dépressions, ainsi que sur des composés associés, leurs intermédiaires ou leurs compositions.

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