N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives

Details N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives

C - Chemistry, Metallurgy

07

D

167/220, 260/242

C07D 487/04 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2031890

N-(Acyl)glutamic acid derivatives as shown below, in which the acyl group is substituted with 4-hydroxypyrrolo [2,3-d]pyrimidin-3-yl group are antineoplastic agents. A typical embodiment is N-[4-(2-(4-hydroxy-6-aminopyrrolo [2,3-d]pyrimidin-3-yl)-ethyl)benzoyl]-L-glutamic acid. (see above formula)

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