C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 217/06 (2006.01) A61K 31/47 (2006.01) A61P 11/06 (2006.01) A61P 13/00 (2006.01) A61P 25/00 (2006.01) A61P 37/00 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2524700
The invention relates to compounds having the Formula (I) or a salt, or a physiologically functional derivative, or a prodrug thereof, (I) wherein Z is carbonyl or sulfonyl; R1 is alkyl, alkenyl, alkynyl, aryl, H, halogen, haloalkyl, haloalkoxy, hydroxyalkyl, cycloalkyl or heteroaryl; R2 is H, OH, - CH2-SO2-alkyl, -CH2-SO2-cycloalkyl, -CH2-SO2-aryl, -CH2-SO2-heteroaryl, alkylamine, alkenylamine, alkynylamine, cycloalkylamine, arylamine, heteroarylamine, aryl, haloalkyl, haloalkoxy, hydroxyalkyl, cycloalkyl, heteroaryl or a linear or branched alkyl, alkenyl, alkynyl, which can optionally be substituted by one or more substituentes R3; R3 is H, alkyl, alkenyl, alkynyl, cycloalkyl, -CO2R4, -CONHR4, -CONR4R4, - CR4O, SO2R4, -NR4- CO-R4, alkoxy, alkylthio, -OH, -SH, -O-aryl, -O-cycloalkyl, -S-aryl, -S- cycloalkyl, hydroxyalkyl, halogen, haloalkyl, haloalkoxy, CN, NO2, hydroxyalkylamine, aminoalkyl, alkylamine, aryl or heteroaryl; R4 is H, halogen, alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, alkylthio, -O-aryl, - O- cycloalkyl, OH, SH, -S-aryl, -S-cycloalkyl, hydroxyalkyl, haloalkyl, haloalkoxy, hydroxyalkyl-amine, aminoalkyl, alkylamine, aryl or heteroaryl; R5 is alkyl, alkenyl or alkynyl.
L'invention concerne des composés de formule (I) ou un sel ou un dérivé physiologiquement fonctionnel ou un promédicament desdits composés, (I) dans laquelle Z représente carbonyle ou sulfonyle; R?1 ¿représente alkyle, alcényle, alkynyle, aryle, H, halogène, haloalkyle, haloalcoxy, hydroxyalkyle, cycloalkyle ou hétéroaryle; R?2¿ représente H, OH, -CH¿2?-SO¿2?-alkyle, -CH¿2?-SO¿2?-cycloalkyle, -CH¿2?-SO¿2?-aryle, -CH¿2?-SO¿2?-hétéroaryle, alkylamine, alcénylamine, alkynylamine, cycloalkylamine, arylamine, hétéroarylamine, aryle, haloalkyle, haloalcoxy, hydroxyalkyle, cycloalkyle, hétéroaryle ou un alkyle linéaire ou ramifié, alcényle, alkynyle, pouvant être facultativement substitué par au moins un substituant R?3¿; R?3¿ représente H, alkyle, alcényle, alkynyle, cycloalkyle, -CO¿2?R?4¿, -CONHR?4¿, -CONR?4¿R?4¿, - CR?4¿O, SO¿2?R?4¿, -NR?4¿-CO-R?4¿, alcoxy, alkylthio, -OH, -SH, -O-aryle, -O-cycloalkyle, -S-aryle, -S-cycloalkyle, hydroxyalkyle, halogène, haloalkyle, haloalcoxy, CN, NO¿2?, hydroxyalkylamine, aminoalkyle, alkylamine, aryle ou hétéroaryle; R?4¿ représente H, halogène, alkyle, alcényle, alkynyle, cycloalkyle, alcoxy, alkylthio, -O-aryle, - O-cycloalkyle, OH, SH, -S-aryle, -S-cycloalkyle, hydroxyalkyle, haloalkyle, haloalcoxy, hydroxyalkyl-amine, aminoalkyle, alkylamine, aryle ou hétéroaryle; R?5¿ représente alkyle, alcényle ou alkynyle.
Garcia Gabriel
Kramer Bernd
Rauer Heiko
Saeb Wael
Vincek Adam Spencer
4sc Ag
Mcmillan Llp
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