C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/10 (2006.01) A61K 31/41 (2006.01) A61K 31/675 (2006.01) C07D 249/12 (2006.01) C07D 405/10 (2006.01) C07D 413/10 (2006.01) C07D 417/10 (2006.01) C07F 9/547 (2006.01)
Patent
CA 2083735
2083735 9118888 PCTABS00008 A class of N-substituted-1,2,4-triazolone compounds is described for use in treatment of cardiovascular disorders. Compounds of particular interest are angiotensin II antagonists of formula (I), wherein R1 is selected from 2-oxo-2-(tricyclo[3.3.1.1.3.7]dec-2-yl)ethyl, 3-phenylpropyl, 2-oxo-2-phenylethyl, 2-hyroxy-2-phenylethyl, 1,1-dimethylethyloxycarbonylmethyl, hexyl, ethoxycarbonylmethyl, carboxymethyl, 1-naphthalenylmethyl, 2-cyclohexylethyl, pentyl, ethoxycarbonylmethoxyethyl substituted with phenyl, carboxymethoxyethyl substituted with phenyl, 3,5,5-trimethylhexyl, (2-phenylmethoxy)-1-(phenylmethyl)-E-ethenyl, 1-benzoyl-2-phenylethyl, 1-oxobutyl, 2-(2,5-dimethyoxyphenyl)-2-oxoethyl, 2-phenyl-2-(phenylmethoxyethyl, 2-(2,5-dimethioxy-phenyl)-2-hydroxyethyl, 2-naphthalenylmethyl, methoxycarbonyl-butyl, ethoxycarbonylethyl substituted with benzoyl, 1-benzyoyl-1-methylethyl, 1-pentanoic acid, cyclopropylmethyl, 3-phenyl-2E-propenyl and 3-acetonitrile; wherein R2 is selected from ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, 4-methylbutyl, tert-butyl, n-pentyl, neopentyl, 1-cyanobutyl, propylthio and butylthio; wherein each of R3 through R11 is hydrido with the proviso that at least one of R5 and R9 must be selected from COOH, SH, PO3H2, SO3H, CONHNH2, CONHNHSO2CF3, OH, (a), (b) and (c), wherein each of R42 and R43 is independently selected from chloro, cyano, nitro, trifluoromethyl, methoxycarbonyl and trifluoromethylsulfonyl. These compounds are particularly useful in treatment or control of hypertension and congestive heart failure.
Huang Horng-Chih
Manning Robert E.
Reitz David B.
Huang Horng-Chih
Manning Robert E.
Osler Hoskin & Harcourt Llp
Reitz David B.
Searle (g. D.) & Co.
LandOfFree
N-substituted-1,2,4-triazolone compounds for treatment of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with N-substituted-1,2,4-triazolone compounds for treatment of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-substituted-1,2,4-triazolone compounds for treatment of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1423925