N-substituted-2-(1-imidazolyl)-indoles

Details N-substituted-2-(1-imidazolyl)-indoles N-substituted-2-(1-imidazolyl)-indoles

C - Chemistry, Metallurgy

07

D

260/305, 260/298

C07D 403/04 (2006.01) C07D 209/08 (2006.01) C07D 209/14 (2006.01) C07D 401/04 (2006.01) C07D 491/056 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1207327

N-Substituted-2-(1-imidazolyl)-indoles Abstract of the Disclosure The invention concerns compounds with thromboxane synthetase inhibitor properties of the formula I (I) Image wherein R1 represents hydrogen or lower alkyl; Im represents 1-imidazolyl unsubstituted or substituted by lower alkyl, carboxy, lower alkoxycarbonyl or carbamoyl; R2 and R3 independently represent hydrogen, lower alkyl, halogen, trifluoromethyl, hydroxy, lower alkoxy, lower alkyl-(thio, sulfinyl or sulfonyl); or R2 and R3 together when attached to adjacent carbons represent lower alkylene- dioxy; A represents alkylene of 1 to 12 carbon atoms, alkenylene of 2 to 12 carbon atoms, alkynylene of 2 to 12 carbon atoms, lower alkylenephenylene-lower alkylene, lower alkylenephenylene, phenylene- lower alkylene, phenylene, a direct bond, lower alkylene-(thio or oxy)-lower alkylene, (thio- or oxy)-phenylene, lower alkylene-(thio- or oxy)-phenylene, phenylene-(thio or oxy)-lower alkylene or phenylene-lower alkenylene; B represents carboxy, lower alkoxycarbonyl, carbamoyl, mono- or di-lower alkylcarbamoyl, cyano, hydroxymethyl, hydroxycarbamoyl, 5-tetrazolyl or formyl; the N-oxides thereof; and salts thereof. They are prepared, for example, by condensing a compound corresponding to the formula I, in which the nitrogen atom carries only a hydrogen atom, with a reactive functional derivative of a compound of the formula HOCH2-A-B.

437785

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