N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-...

Details N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-... N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-...

C - Chemistry, Metallurgy

07

D

260/266.9

C07D 409/04 (2006.01) C07D 337/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01)

Patent

CA 1238047

ABSTRACT OF THE DISCLOSURE: The invention relates to N-substituted 2-chloro-7- fluoro 10-piperazino-10,11-dihydrodibenzo/b,f/thiepins of the general formula I Image ( I ) in which R represents an aminocarbonyl, amino-oximinomethyl, 1,3-dioxolan-2-yl or 1,3 dioxan-2-yl group, and their pharma- ceutically acceptable addition salts with organic and inor- ganic acids. These compounds are highly potent anti- dopaminergic, non-cataleptic neuroleptics of presumed use in the treatment of schizophrenia; according to recent pharmaco- logical assay results, the subject compounds are expected to be substantially free of the usual undesired extrapyramidal side effects. The invention also relates to a process for the preparation of these compounds.

498881

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