N-substituted 2-ixindole-1-carboxamides useful as...

Details N-substituted 2-ixindole-1-carboxamides useful as... N-substituted 2-ixindole-1-carboxamides useful as...

C - Chemistry, Metallurgy

07

D

260/207.7

C07D 209/34 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 1287626

ABSTRACT OF THE DISCLOSURE Certain 2- oxindole-1-carboxamide compounds substituted of the carboxamide nitrogen of the formula: Image -- (V) [wherein X and Y are each hydrogen, 5-fluoro, 6-fluoro, 5-chloro, 6-chloro, 5-trifluoromethyl or 6-trifluoromethyl, provided that X and Y are not both hydrogen; and R2 is alkyl having from 1 to 6 carbons, cycloalkyl having from 3 to 7 carbons, benzyl, furyl, thienyl, pyridyl or a group of the formula Image (wherein R3 and R4 are each hydrogen, fluoro, chloro, alkyl having 1 to 4 carbons, alkoxy having 1 to 4 carbons or trifluoromethyl)?, are useful as intermediates for producing 3-acyl substituted 2- oxindole-1-carboxamides which are analgesic and antiinflammatory agents.

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