N-substituted-6-oxamorphinans

Details N-substituted-6-oxamorphinans N-substituted-6-oxamorphinans

C - Chemistry, Metallurgy

07

D

260/237.8

C07D 491/08 (2006.01) C07D 221/26 (2006.01)

Patent

CA 1100496

ABSTRACT OF THE DISCLOSURE N-substituted 6-oxamorphinans have been found to possess potent analgetic, narcotic antagonist, antitussive and ADH inhibitory activity. A particularly preferred comtpound is (-)-17-cyclopropylmethyl-3-hydroxy-6-oxamorphinan. The compounds are prepared by total synthesis and are not derived from opium alkaloids.

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