C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/277.1
C07D 405/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 1193259
ABSTRACT N-SUBSTITUTED ANTHANILIC ACID ESTER Anthranilic acid esters I n = 0,1,2; one of R1 and R2 = C1, CF3, the other = H; Image R = 2-oxo-3-oxolanyl or 2-oxo-3-oxazolidinyl have analgesic and anti-inflammatory properties. They are prepared by condensing a salt (preferably Na) of an N-(7- or 8-substituted-4-quinolyl)- -anthranilic acid with a haloderivative Halo-(CH2) -R. The condensation conditions are suitably equimolar proportions, 30 to 150°C, DMF as solvent. Pharmaceutical preparations are also disclosed.
412422
Casadio Silvano
Graziani Gabriele
Motta Gianni
Nardi Dante
Testa Rodolfo
Borden Ladner Gervais Llp
Recordati S.a. Chemical And Pharmaceutical Company
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