N-substituted anthranilic acid esters

C - Chemistry – Metallurgy – 07 – D

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260/277.1

C07D 405/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 1193259

ABSTRACT N-SUBSTITUTED ANTHANILIC ACID ESTER Anthranilic acid esters I n = 0,1,2; one of R1 and R2 = C1, CF3, the other = H; Image R = 2-oxo-3-oxolanyl or 2-oxo-3-oxazolidinyl have analgesic and anti-inflammatory properties. They are prepared by condensing a salt (preferably Na) of an N-(7- or 8-substituted-4-quinolyl)- -anthranilic acid with a haloderivative Halo-(CH2) -R. The condensation conditions are suitably equimolar proportions, 30 to 150°C, DMF as solvent. Pharmaceutical preparations are also disclosed.

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