C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/292, 260/294
C07D 207/16 (2006.01) A61K 31/445 (2006.01) C07D 211/18 (2006.01) C07D 405/06 (2006.01)
Patent
CA 1291995
N-SUBSTITUTED-ARYLALKYL AND ARYLALKYLENE AMINOHETEROCYCLICS AS CARDIOVASCULAR ANTIHISTAMINIC AND ANTISECRETORY AGENTS ABSTRACT OF THE INVENTION Methods of countering cardiovascular disturbances and the effects of histamine and excessive gastric secretion are disclosed wherein the active agents are expressed generally by the formula: Image wherein: p is zero, one or two; m is one to six inclusive; A is hydrogen, -O-R1, -C?N, -C(O)NR1R2, -C(O)R1, -C(O)-OR1, -CH2OR1, -CH2NR1R2, or -OC(O)R1; Q is -CH-, -CH2- or Image ; d and n are zero or one and the dotted lines represent double bonds which may form consistent with the valence of carbon; B is O, S, -S(O)-, -S(O)2-, Image , and -?-C(O)OR1; Ar, D and R are selected from phenyl and substituted phenyl with certain limitations, pyridinyl, thienyl, furanyl or naphthyl and, in addition, R may have the values: benzyl, substituted benzyl, cycloalkyl or loweralkyl, and D may additionally have the values: 2H-1-benzopyran-2-one, 4-oxo-4H-1-benzopyran-2-carboxylic acid loweralkyl ester, 1,4-benzodioxanloweralkyl-2-yl or quinolinyl, and the pharmaceutically acceptable addition salts thereof.
526931
Proakis Anthony G.
Shanklin James R. Jr.
A.h. Robins Company
Proakis Anthony G.
Robins (a.h.) Company Incorporated
Shanklin James R. Jr.
Smart & Biggar
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