N-substituted benzothiophenesulfonamide derivative

Details N-substituted benzothiophenesulfonamide derivative N-substituted benzothiophenesulfonamide derivative

C - Chemistry, Metallurgy

07

D

C07D 333/62 (2006.01) A61K 31/381 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/06 (2006.01) A61P 13/12 (2006.01) A61P 17/02 (2006.01) A61P 17/06 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2479353

The present invention can provide an N--substituted benzothiophenesulfonamide derivative having a specific structure or a pharmaceutically acceptable salt thereof, which has excellent inhibitory activity on chymase and enzyme selectivity, or a chymase inhibitor and a medicine containing the same.

L'invention porte sur un dérivé du benzothiophènesulfonamide substitué en n de formule (I), ou sur un de sels pharmacocompatibles. Ce composé est excellent du point de vue de son activité inhibitrice de la chymase humaine et de sa sélectivité des enzymes. L'invention porte également sur un inhibiteur de la chymase et sur un médicament, contenant tous deux ledit dérivé ou ledit sel. (Les substituants sont définis dans la revendication 1)

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