N-substituted benzothiophenesulfonamide derivatives

Details N-substituted benzothiophenesulfonamide derivatives N-substituted benzothiophenesulfonamide derivatives

C - Chemistry, Metallurgy

07

D

C07D 333/62 (2006.01) A61K 31/381 (2006.01) A61K 31/4025 (2006.01) A61K 31/4178 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61P 9/10 (2006.01) A61P 43/00 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2422807

The present invention relates to an N-substituted benzothiophenesulfonamide derivative or a salt thereof and applications thereof. Furthermore, it provides an agent for preventing or treating cardiac or circulatory disease caused by abnormal increase of production of angiotensin II or endothelin I based on chymase activity, wherein the agent has a selective inhibitory action on chymase.

L'invention concerne de nouveaux dérivés de benzothiophènesulfonamide substitué en N représentés par la formule générale (I) ou leurs sels et leur utilisation. L'invention concerne également des médicaments préventifs ou curatifs destinés aux maladies cardiovasculaires dues à l'hyperproduction d'angiotensine II ou d'endothéline I et basés sur l'activité de la chymosine et ayant un effet d'inhibition sélective de la chymosine.

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