N-substituted derivatives of 5-oxyiminobarbituric acid

Details N-substituted derivatives of 5-oxyiminobarbituric acid N-substituted derivatives of 5-oxyiminobarbituric acid

C - Chemistry, Metallurgy

07

D

C07D 239/62 (2006.01) A61K 31/515 (2006.01) C07D 239/60 (2006.01) C07D 239/66 (2006.01)

Patent

CA 2333537

The present invention pertains to the field of medicine and essentially relates to synthetic biologically active compounds of the heterocyclic series having a wide range of biological activities. This invention more precisely relates to compounds of N-substituted derivatives of 5-oxyiminobarbituric acid of general formula (I) where [X] is an oxygen or sulphur atom, R1 is selected from the group comprising saturated or unsaturated alkanes, cycloalkanes, arylalkanes and aromatic compounds, and (R2) is a hydrogen atom or is selected from the group comprising saturated or unsaturated alkanes, cycloalkanes, arylalkanes and aromatic compounds having a biological activity. The compounds of general formula (I) exhibit an anti-viral activity (concerning the herpes simplex viruses), an immuno-stimulating activity, an anti-chlamydial and anti- tuberculosis activity as well as anti-microbial, anti-aggregating, psycho- stimulating, psycho-depressive, anti-oxidant, analgesic, hypoglycemic, anti- arteriosclerosis, anti-ulcer and hepatic-protection activities.

Cette invention se rapporte au domaine de la médecine et concerne essentiellement des composés synthétiques, biologiquement actifs et du type hétérocycliques qui possèdent une gamme étendue d'actions biologiques. Cette invention concerne plus précisément des composés de dérivés N-substitués d'acide 5-oxyiminobarbiturique qui correspondent à la formule générale (I) où X représente un atome d'oxygène ou de soufre, R1 est choisi dans le groupe comprenant des composés aromatiques, des arylalcanes, des cycloalcanes et des alcanes saturés ou insaturés et, enfin, R2 représente un atome d'hydrogène ou est choisi dans le groupe comprenant des composés aromatiques, des arylalcanes, des cycloalcanes et des alcanes saturés ou insaturés qui possèdent une activité biologique. Les composés correspondant à la formule générale (I) ont une action antivirale (en ce qui concerne les virus de l'herpès simplex), une action immuno-stimulatrice, une action anti-chlamydiose et antituberculeuse, ainsi que des actions antimicrobienne, antiagrégante, psycho-stimulatrice, psycho-dépressive, antioxydante, analgésique, hypoglycémique, anti-artérioscléreuse, anti-ulcère et de protection hépatique.

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