C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 5/02 (2006.01) A61K 31/69 (2006.01)
Patent
CA 2193644
Novel N-substituted-(dihydroxyboryl)alkyl purine, indole and pyrimidine derivatives have been found to be useful as inhibitors of inflammatory cytokines. They can be used, inter alia, in the therapy of septic shock, cachexia, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and AIDS. The compounds are typically prepared by reaction of a bromoalkyl boronic acid with the purine, indole or pyrimidine base.
On a découvert que des nouveaux dérivés, à savoir la purine, l'indol et la pyrimidine de (dihydroxyboryl)alkyle à substitution en N, peuvent être utilisés comme inhibiteurs de cytokines inflammatoires. Ces dérivés peuvent être utilisés, entre autres, dans le traitement du choc septique, de la cachexie, de la polyarthrite rhumatoïde, de l'affection abdominale inflammatoire, de la sclérose multiple et du SIDA. Les composés sont généralement préparés par réaction d'un acide bromoalkylboronique avec la base purine, indol ou pyrimidine.
Benson Bradley J.
Chen Xiannong
Cianciolo George J.
Diaz Jose-Luis
Ishaq Khalid S.
Macronex Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
University Of North Carolina
University Of North Carolina At Chapel Hill
LandOfFree
N-substituted-(dihydroxyboryl)alkyl purine, indole and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with N-substituted-(dihydroxyboryl)alkyl purine, indole and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-substituted-(dihydroxyboryl)alkyl purine, indole and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1564444