C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/10 (2006.01) A61K 31/505 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 209/00 (2006.01) C07D 239/00 (2006.01)
Patent
CA 2480092
The present invention relates to N-substituted-heteroaryloxy-aryl-spiro- pyrimidine- 2,4,6-trione metalloproteinase inhibitors of the formula wherein ring X is a 5-7 membered heterocyclic ring, and wherein A, Y, B, and G are as defined in the specification; and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.
La présente invention concerne des inhibiteurs de la métalloprotéinase N-substitués-hétéroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione, représentés par la formule suivante dans laquelle le noyau X est un noyau hétérocyclique à 5-7 chaînons, et dans laquelle A, Y, B, et G sont tels que définis dans les spécifications. L'invention concerne également des compositions pharmaceutiques et des méthodes de traitement de l'inflammation, du cancer et d'autres troubles.
Freeman-Cook Kevin Daniel
Noe Mark Carl
Pfizer Products Inc.
Smart & Biggar
LandOfFree
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