N-substituted indoles useful in the treatment of diabetes

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 209/08 (2006.01) A61K 31/404 (2006.01) A61K 31/405 (2006.01) C07D 209/12 (2006.01)

Patent

CA 2415742

Certain N-substituted indoles having aryloxyacetic acid substituents are agonists or partial agonists of PPAR gamma, and are useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, obesity, vascular restenosis, inflammation, and other PPAR mediated diseases, disorders and conditions.

Certaines indoles N-substitués comprenant des substituants à base d'acide aryloxyacétique sont des agonistes ou des agonistes partiels des PPAR gamma, et sont utiles pour le traitement, le contrôle ou la prévention du diabète non insulino-dépendant, de l'hyperglycémie, de la dyslipidémie, de l'hyperlipidémie, de l'hypercholestérolémie, de l'hypertriglycéridémie, de l'athérosclérose, de l'obésité, de la resténose vasculaire, de l'inflammation ainsi que d'autres maladies, troubles et états pathologiques induits par les PPAR.

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