C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/08 (2006.01) A61K 31/404 (2006.01) A61K 31/405 (2006.01) C07D 209/12 (2006.01)
Patent
CA 2415742
Certain N-substituted indoles having aryloxyacetic acid substituents are agonists or partial agonists of PPAR gamma, and are useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, obesity, vascular restenosis, inflammation, and other PPAR mediated diseases, disorders and conditions.
Certaines indoles N-substitués comprenant des substituants à base d'acide aryloxyacétique sont des agonistes ou des agonistes partiels des PPAR gamma, et sont utiles pour le traitement, le contrôle ou la prévention du diabète non insulino-dépendant, de l'hyperglycémie, de la dyslipidémie, de l'hyperlipidémie, de l'hypercholestérolémie, de l'hypertriglycéridémie, de l'athérosclérose, de l'obésité, de la resténose vasculaire, de l'inflammation ainsi que d'autres maladies, troubles et états pathologiques induits par les PPAR.
Acton John J. III
Black Regina Marie
Jones Anthony Brian
Wood Harold Blair
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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