C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/471, 260/247
C07D 317/30 (2006.01) C07C 51/08 (2006.01) C07C 51/09 (2006.01) C07C 51/367 (2006.01) C07C 51/377 (2006.01) C07D 295/13 (2006.01)
Patent
CA 1182818
Abstract Mammalian collagenase is inhibited by compounds having the formula Image or a salt thereof, wherein R1 is hydrogen, alkanoyl of 2 to 10 carbon atoms, or arylcarbonyl; Image 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 1- piperazinyl or 4-alkyl-1-piperazinyl wherein R4 is hydrogen, alkyl or aryl; R3 is alkyl of 3 to 8 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, aryl or arylalkyl; and n is an integer of 1 to 20.
376389
Dejneka Tamara
Sundeen Joseph E.
Osler Hoskin & Harcourt Llp
Squibb (e.r.) & Sons Inc.
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