N-(substituted-naphthoyl)glycine derivatives

Details N-(substituted-naphthoyl)glycine derivatives N-(substituted-naphthoyl)glycine derivatives

C - Chemistry, Metallurgy

07

C

260/472.3, 260/5

C07C 103/375 (1980.01)

Patent

CA 1188318

ABSTRACT The disclosure describes a process for preparing a compound of Formula II Image (II) wherein R1 is lower alkyl, R3 is a lower alkoxy at positior 6 of the naphthalene ring and R4 and R5 each is hydrogen, or R3, R and R5 each is a substituent at different positions selected from positions 4, 5 and 6 of the naphthalene ring, the substituent being selected from the group consisting of lower alkoxy, halo and trihalomethyl; and R is lower alkyl or ar(lower)alkyl; or a compound of Formula IV Image wherein R1, R3, R4 and R5 are as defined above. The process comprises coupling a naphthalenecarboxylic acid of the Formula Image wherein R3, R4 and R5 are as defined above with an aminoacid ester of formula NH(R1)-CH2COOR wherein R1 and R are as defined above to obtain the corresponding compound II in which R1, R3, R4, R5 and R are as defined above. These compounds are intermediates useful for the preparation of N-(substituted- naphthoyl)glycine derivatives which have aldose reductase inhibiting activity and can be used for treating diabetic complication.

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