N-substituted phenylacetamide derivative and pharmaceutical...

Details N-substituted phenylacetamide derivative and pharmaceutical... N-substituted phenylacetamide derivative and pharmaceutical...

C - Chemistry, Metallurgy

07

C

C07C 235/36 (2006.01) A61K 31/165 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2605351

A compound represented by the formula: (I) wherein R1 represents a methoxy group, a hydroxyl group or a hydrogen atom; R2 represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkylcarbonyl group or an arylcarbonyl group; and D represents a group represented by the formula (A), (B) or (C) below. (A) (B) (C) This compound is useful as a therapeutic agent for a pain or inflammation induced by any one of various morbid conditions such as neuropathic pain, rheumatoid arthritis and osteoarthritis.

L'invention concerne un composé représenté par la formule (I) où R1 représente un groupe méthoxy, un groupe hydroxyle ou un atome d'hydrogène ; R2 représente un atome d'hydrogène, un groupe alkyle en C1-4, un groupe alkylcarbonyle en C1-4 ou un groupe arylcarbonyle ; et D représente un groupe selon la formule (A), (B) ou (C) annexée. Ce composé est utile comme agent thérapeutique pour une douleur ou une inflammation induite par l'un des divers états morbides possibles tels qu'une douleur neuropathique, une polyarthrite rhumatoïde et une ostéoarthrite.

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