C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/30 (2006.01) A61K 31/13 (2006.01) A61K 31/135 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07C 291/08 (2006.01) C07C 307/02 (2006.01) C07D 295/28 (2006.01) C07F 9/6509 (2006.01)
Patent
CA 2223426
There are disclosed N-substituted piperazine NONOate compounds having structure (I) wherein M is a pharmaceutically acceptable cation, x is the valence of the cation, and R is selected from the group consisting of: an unsubstituted or substituted C1-C20 straight chain alkyl, an unsubstituted or substituted C3-C20 branched chain alkyl, an unsubstituted or substituted C2- C20 straight chain alkenyl, an unsubstituted or substituted C3-C20 branched chain alkenyl, a group of formula (II), a group of formula (III), a group of formula R4-SO2-, or a group of formula R5-O-N=N(O)-. The compounds are potent nitric oxide releasing compounds.
L'invention concerne des composés NONOates de pipérazine N-substitués de structure (I), dans laquelle M est un cation pharmaceutiquement acceptable, x est la valence du cation et R est sélectionné dans le groupe constitué d'un alkyle C¿1?-C¿20? à chaîne droite substitué ou non, d'un alkyle C¿3?-C¿20? à chaîne ramifiée substitué ou non, d'un alcényle C¿2?-C¿20? à chaîne droite substitué ou non, d'un alcényle C¿3?-C¿20? à chaîne droite substitué ou non, d'un groupe de formule (II), d'un groupe de formule (III), d'un groupe de formule R?4¿-SO¿2?-, ou d'un groupe de formule R?5¿-O-N=N(O)-. Ces composés sont des puissants agents de libération d'oxyde nitrique.
Hrabie Joseph Anthony
Keefer Larry Kay
Saavedra Joseph E.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The United States Of America Represented By The Secretary Department Of Health And Human Services National Institute Of He
United States Of America Represented By The Secretary Of The Department Of Health And Hum
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