N-substituted spiropiperidine compounds as ligands for orl-1...

Details N-substituted spiropiperidine compounds as ligands for orl-1... N-substituted spiropiperidine compounds as ligands for orl-1...

C - Chemistry, Metallurgy

07

D

C07D 487/06 (2006.01) A61K 31/4709 (2006.01) A61K 31/4738 (2006.01) A61K 31/5383 (2006.01) A61P 25/04 (2006.01) A61P 25/28 (2006.01) C07D 401/06 (2006.01) C07D 487/10 (2006.01) C07D 491/10 (2006.01) C07D 498/06 (2006.01)

Patent

CA 2466915

A compound of formula (I) or a pharmaceutically acceptable salt, ester or ether thereof, wherein R1 through R12 are independently hydrogen or the like; X1 and X2 are independently CH2 or the like; R13 is hydrogen or the like; or R12 and R13 taken together with three ring atoms of the quinoline ring separating said substituents form a heterocyclic ring; R14 and R15 are hydrogen or the like or these groups taken together form oxo; and the dotted line represents a single or double bond. These compounds are ligands for ORL-1 receptor and especially are antagonists for said receptor.

L'invention concerne un composé représenté par la formule (I) ou un sel, ester ou éther pharmaceutiquement acceptable dudit composé. Dans cette formule, R?1¿ à R?12¿ représentent indépendamment hydrogène ou des éléments analogues ; X?1¿ et X?2¿ représentent indépendamment CH¿2 ou des éléments analogues ; R?13¿ représente hydrogène ou des éléments analogues ; ou R?12¿ et R?13¿ conjointement avec trois atomes cycliques du noyau quinoline séparant lesdits substituants forment un noyau hétérocyclique ; R?14¿ et R?15¿ représentent hydrogène ou des éléments analogues ; ou ces groupes forment conjointement oxo ; et la ligne pointillée représente une liaison simple ou double. Ces composés, qui sont des ligands pour le récepteur ORL-1, sont notamment des antagonistes dudit récepteur.

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