N-substituted tricyclic 3-aminopyrazoles as pdfg receptor...

C - Chemistry – Metallurgy – 07 – D

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C07D 231/54 (2006.01) A61K 31/416 (2006.01) A61P 35/04 (2006.01) C07D 231/56 (2006.01) C07D 233/54 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01) C07D 498/04 (2006.01) C07F 9/6503 (2006.01)

Patent

CA 2486097

The invention is directed to N-substituted tricyclic 3-AMINOPYRAZOLE derivatives, which are useful as inhibitors of platelet-derived growth factor receptor (PDGF-R) kinase, and methods for the preparation of said derivatives. The present invention is further directed to pharmaceutical compositions comprising the compounds of the presentinvention and to methods for treating conditions such as tumors and other cell proliferative disorders.

L'invention concerne des dérivés de 3-aminopyrazole tricycliques N-substitués qui sont utilisés comme inhibiteurs de la kinase du récepteur du facteur de croissance dérivé des plaquettes (PDGF-R), ainsi que des procédés de préparation de ces dérivés. Par ailleurs, l'invention concerne des compositions pharmaceutiques qui contiennent des composés de l'invention ainsi que des procédés de traitement d'états pathologiques tels que les tumeurs et d'autres problèmes de prolifération cellulaire.

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