N-substituted trifluoromethylphenyltetrahydropyridines,...

Details N-substituted trifluoromethylphenyltetrahydropyridines,... N-substituted trifluoromethylphenyltetrahydropyridines,...

C - Chemistry, Metallurgy

07

D

C07D 211/70 (2006.01) A61K 31/44 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2043136

New N-substituted 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridines useful in the treatment of intestinal motility disorders, of the following general formula Image (I) wherein A represents a group -E-G or -L-M, where -E- is a straight or branched alkylene radical of from 2 to 4 carbon atoms, -G represents a radical selected from the group consisting of naphthyl mono-substituted with hydroxy or (C1-C4)alkoxy; naphthyl di-substituted with hydroxy, (C1-C4)alkoxy or (C1-C4)alkyl; or naphthyl substituted with methylenedioxy, -L- is a -Q-CH(OH)- group wherein -Q- is a straight or branched alkylene radical of from 1 to 3 carbon atoms, and -M represents a radical selected from the group consisting of naphthyl; naphthyl mono- or di-substituted with hydroxy, (C1-C4)alkoxy or (C1-C4)alkyl or naphthyl substituted with methylenedioxy; pyridyl; or (C1-C4)alkyl-pyridyl, and their salts with mineral or organic acids.

Nouvelles 4-(3-trifluorométhylphényl)-1,2,3,6-tétrahydropyridines N-substituées utiles dans le traitement des troubles de la motilité intestinale, de formule générale suivante Image (I) où A représente un groupe -E-G ou -L-M, où -E- est un radical alkylène linéaire ou ramifié de 2 à 4 atomes de carbone, -G représente un radical choisi parmi le groupe suivant : naphtyle mono-substitué portant un hydroxy ou un alcoxy en C1-C4, naphtyle di-substitué portant un hydroxy, un alcoxy en C1-C4 ou un alkyle en C1-C4, ou naphtyle substitué portant un méthylènedioxy; -L- est un groupe -Q-CH(OH)- où -Q- est un radical alkylène linéaire ou ramifié de 1 à 3 atomes de carbone, et -M représente un radical choisi parmi le groupe suivant : naphtyle; naphtyle mono- ou di-substitué portant un hydroxy, un alcoxy en C1-C4 ou un alkyle en C1-C4 ou naphtyle substitué portant un méthylènedioxy; un pyridyle; ou alkyle en C1-C4-pyridyle, et leurs sels formés avec des acides minéraux ou organiques.

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