C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 451/00 (2006.01) A61K 31/438 (2006.01) A61K 31/46 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2736767
The current invention provides compounds having a structure according to Formulae (1), (2), (3), and (4): wherein the A-ring, B-ring, C-ring, m, n, R25, R50, and R51 are as described in the specification. The invention also provides pharmaceutical compositions comprising compounds of Formulae (1), (2), (3), and (4), as well as methods of treating cognitive disorders, such as Alzheimer's disease. The invention further provides intermediates useful in preparing the compounds of Formulae (1), (2), (3), and (4).
La présente invention concerne des composés possédant une structure selon les formules (1), (2), (3), et (4), avec le cycle A, le cycle B, le cycle C, m, n, R25, R50, et R51 étant tels que définis dans la description. Linvention concerne également des compositions pharmaceutiques comprenant des composés de formules (1), (2), (3), et (4), ainsi que des procédés de traitement de troubles cognitifs, tels que la maladie dAlzheimer. Linvention porte en outre sur des produits semi-ouvrés utiles dans la préparation des composés de formule (1), (2), (3), et (4).
Aubele Danielle L.
Bowers Simeon
Dappen Michael S.
Dressen Darren
Garofalo Albert W.
Elan Pharmaceuticals Inc.
Mbm Intellectual Property Law Llp
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