C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/42 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) C07C 311/08 (2006.01) C07C 311/13 (2006.01) C07C 311/21 (2006.01) C07D 403/06 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2048139
N-Sulfonylindoline derivatives of the formula (see formula I) in which - R1 is a halogen atom, a C1-C4 alkyl, a hydroxyl, a C1-C4 alkoxy, a benzyloxy group, a cyano group, a trifluoromethyl group, a nitro group or an amino group; - R2 is a C1-C6 alkyl, a C3-C7 cycloalkyl, a C5-C7 cycloalkene or a phenyl which is unsubstituted or monosubstituted or polysubstituted by a C1-C4 alkyl, a C1-C4 alkoxy, a halogen, a trifluoromethyl group, a nitro group or an amino group; - R3 is a hydrogen atom or a C1-C4 alkyl; - R4 is a carboxyl group, an alkoxycarbonyl group in which the alkyl group is C1-C8, a benzyloxycarbonyl group or a carboxamide group of the formula CONR6R7; - R5 is a C1-C4 alkyl, a 1-naphthyl, a 2-naphthyl, a 5- dimethylamino-1-naphthyl or a phenyl which is unsub- stituted or substituted by one or more substituents selected from a halogen atom, a C1-C4 alkyl, a tri- fluoromethyl group, a nitro group, an amino group which is free or substituted by one or 2 C1-C4 alkyls, a hydroxyl, a C1-C4 alkoxy, a C1-C4 alkenoxy, a C1-C4 alkylthio, a trifluoromethoxy group, a ben- zyloxy group, a cyano group, a carboxyl group, a C1- C4 alkoxycarbonyl group, a carbamoyl group or a C1-C4 alkylamido group, or, when m = 0, R5 can be a group Image - R6 and R7 are each independently hydrogen, a C1-C6 alkyl or a phenylalkyl in which the alkyl is C1-C4, or R6 and R7 together form a group -(CH2)p- - n is 0, 1 or 2; - m is 0, 1 or 2; and - p is 4, 5 or 6; and their salts, where appropriate.
de Cointet Paul
Nisato Dino
Plouzane Claude
Serradeil-Legal Claudine
Wagnon Jean
Sanofi
Sanofi-Synthelabo
Sim & Mcburney
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