N-sulfonylpiperidines as metalloproteinase inhibitors (tace)

Details N-sulfonylpiperidines as metalloproteinase inhibitors (tace) N-sulfonylpiperidines as metalloproteinase inhibitors (tace)

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/445 (2006.01) A61K 31/4545 (2006.01) A61K 31/4709 (2006.01) A61K 31/506 (2006.01) A61P 19/02 (2006.01) C07D 211/96 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2492083

Compounds of formula (1), wherein Z is -CONR15OH or -N(OH)CHO and X is - (CR9R10)t-Q-(CR11R12)u- (where t and u are independently 0 or 1 with the proviso that t and u cannot both be 0);are inhibitors of metalloproteinases and in particular TACE.

Cette invention a trait à des composés, correspondant à la formule (I), et qui sont des inhibiteurs des métalloprotéase, notamment de l'enzyme de conversion du facteur de nécrose tumorale .alpha. (TACE). Dans cette formule, Z représente -CONR?15¿OH ou -N(OH)CHO et X représente -(CR?9¿R?10¿)t-Q-(CR?11¿R?12¿)u- (les valeurs de t et de u étant, de façon indépendante de 0 ou de 1, à la condition que t et u ne puissent pas valoir tous les deux 0).

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