N-t-butylaniline analog and lipid level depressant...

Details N-t-butylaniline analog and lipid level depressant... N-t-butylaniline analog and lipid level depressant...

C - Chemistry, Metallurgy

07

C

C07C 323/37 (2006.01) A61K 31/135 (2006.01) A61K 31/16 (2006.01) C07C 317/34 (2006.01) C07C 317/36 (2006.01) C07C 323/41 (2006.01)

Patent

CA 2147495

The invention relates to N-t-butylaniline analog represented by formula (I): Image ( I ) wherein R1 and R2 are the same or different and represent a hydrogen atom, halogen atom, amino group, nitro group, acetamido group, lower alkyl group, lower alkoxy group, halogeno lower alkyl group, halogeno lower alkoxy group or lower alkanoyl group, R3 represents a hydrogen atom, halogen atom, lower alkoxy group or halogeno lower alkyl group, and Z represents S, SO or SO2, as well as a salt thereof. A lipid level depressant containing the same is also claimed. The compound of the invention has a remarkable effect of depressing the lipid level as compared with clofibrate and 4-(N-t-butyl)methanesulfonylaminodiphenyl ether and is extremely low toxicity. 28

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