C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 31/7088 (2006.01) A61K 38/18 (2006.01) A61P 9/00 (2006.01) A61P 19/00 (2006.01) C07K 14/50 (2006.01) C12N 5/02 (2006.01)
Patent
CA 2664921
The present invention relates to the design, manufacture and use of fibroblast growth factor (FGF) polypeptides having improved receptor specificity. In particular, the invention relates to isolated FGF2 and FGF4 polypeptides comprising a truncated N-terminus and optionally N-terminal amino acid substitutions. The present invention provides polypeptides, nucleic acids encoding the polypeptides, compositions comprising same and methods for use thereof.
La présente invention concerne la conception, la fabrication et l'utilisation de polypeptides d'un facteur de croissance de fibroblaste (FGF) ayant une spécificité de récepteur améliorée. L'invention concerne en particulier des polypeptides FGF2 et FGF4 isolés comprenant un N-terminus tronqué et en option des substitutions d'acides aminés N-terminal. La présente invention a trait à des polypeptides, des acides nucléiques encodant les polypeptides, des compositions les comprenant et des procédés d'utilisation correspondant.
Blumenstein Sara
Chumakov Irina
Rom Eran
Yayon Avner
Hepacore Ltd.
Prochon Biotech Ltd.
Ridout & Maybee Llp
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