N-terminally chemically modified protein compositions and...

Details N-terminally chemically modified protein compositions and... N-terminally chemically modified protein compositions and...

C - Chemistry, Metallurgy

07

K

C07K 17/08 (2006.01) A61K 47/48 (2006.01) C07K 1/107 (2006.01) C07K 14/535 (2006.01) C07K 14/555 (2006.01) C07K 14/56 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2178752

Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon.

On décrit des procédés et des compositions permettant de fixer des polymères hydrosolubles à des protéines. On décrit de nouveaux procédés pour réaliser une modification N-terminale sur des protéines ou leurs analogues, ainsi que les compositions résultantes, en particulier des compositions du facteur stimulant les colonies de granulocytes, modifié au niveau du N terminal, ainsi que des procédés de préparation associés. On décrit également l'interféron consensus modifié chimiquement.

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