N-terminally chemically modified protein compositions and...

Details N-terminally chemically modified protein compositions and... N-terminally chemically modified protein compositions and...

C - Chemistry, Metallurgy

07

K

C07K 17/08 (2006.01) A61K 47/48 (2006.01) C07K 1/107 (2006.01) C07K 14/535 (2006.01) C07K 14/555 (2006.01)

Patent

CA 2307142

Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon.

On fournit ici des méthodes et des compositions relatives à la fixation de polymères hydrosolubles sur des protéines. Il s'agit de méthodes nouvelles pour les protéines modificatrices du N terminal ou leurs analogues, et des compositions qui en résultent, dont des compositions de facteur G-SCF chimiquement modifié au niveau du N terminal et les méthodes de préparations connexes. On propose également un interféron consensus chimiquement modifié.

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