G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/574 (2006.01) C12Q 1/00 (2006.01) C12Q 1/48 (2006.01) G01N 33/53 (2006.01) G01N 33/563 (2006.01) G01N 33/567 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2350834
There is disclosed an initial identification of an N-terminally truncated HER- 2/neu product. This product is a 95kDa polypeptide having in vitro kinase activity (as determined by western blotting). Moreover, immunoprecipitations using domain specific antibodies was able to utilize this specific polypeptide from intracellular fragments as a diagnostic and prognostic indicator of adenomacarcinomas without the severe dilution effects encountered by measuring ECD.
La présente invention concerne l'identification initiale d'un produit HER-2/neu tronqué à l'extrémité N-terminale. Ce produit est un polypeptide de 95kDa présentant une activité kinase in vitro (telle que déterminée par la méthode d'immunotransfert "Western blotting"). Par ailleurs, des immunoprécipitations employant des anticorps spécifiques aux domaines ont pu utiliser ce polypeptide spécifique provenant de fragments intracellulaires comme indicateur pour le diagnostic et le pronostic d'adénomes carcinogènes, sans subir les effets extrêmes de dilution rencontrés avec les mesures dans le domaine extracellulaire (ECD).
Oregon Health And Science University
Oregon Health Sciences University
Smart & Biggar
LandOfFree
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