N-terminus modified analogs of lhrh

Details N-terminus modified analogs of lhrh N-terminus modified analogs of lhrh

C - Chemistry, Metallurgy

07

K

C07K 7/23 (2006.01) A61K 38/09 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2167834

Decapeptide and undecapeptides substituted on the N-terminal nitrogen atom by acyl groups which include furo-2-yl, isonicotinyl, nicotinyl, 2-, 3-, and 4-quinolinecarbonyl, shikimyl, dihydroshikimyl, and tetrahydrofur-2-oyl are potent antagonists of LHRH and are useful for hormones the levels of sex hormones in mammals.

L'invention concerne des décapeptides et des undécapeptides substitués sur l'atome d'azote N-terminal par des groupes acyle qui comprennent furo-2-yl, isonicotinyle, nicotinyle, 2-, 3- et 4-quinoléinecarbonyle, shikimyle, dihydroshikimyle, et tétrahydrofur-2-oyl qui sont des antagonistes puissants de LHRH et sont utilisés pour diminuer les taux d'hormones sexuelles chez les mammifères.

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