N-(tetrazol-5-yl) prostaglandin carboxamides

Details N-(tetrazol-5-yl) prostaglandin carboxamides N-(tetrazol-5-yl) prostaglandin carboxamides

C - Chemistry, Metallurgy

07

D

260/235.01

C07D 257/06 (2006.01) C07C 405/00 (2006.01) C07D 257/04 (2006.01)

Patent

CA 1152502

P.C. 5935A N-(Tetrazol-5-yl) Prostaglandin Carboxamides Abstract Three classes of N-(tetrazol-5-yl) prostaglandin carboxamides having the bottom side chain substitutions of C-16 phenyl or substituted phenyl (Class 1), C-16 phenoxy or substituted phenoxy tClass 2) and C-15 n-pentyl, 2-hexyl or 2-methyl-2-hexyl (Class 3) have been synthesied using the corresponding acyk imidazole intermediates and 5-amino tetrazole. The three classes of prostaglandins have different and selective biologi- cal activities which are antiulcer (Class 1), fertility control (Class 2) and bronchodilator or fertility control (Class 3).

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