C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/06 (2006.01) A61K 31/4184 (2006.01) A61K 31/4245 (2006.01) C07D 235/04 (2006.01) C07D 401/06 (2006.01) C07D 403/04 (2006.01) C07D 405/06 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01)
Patent
CA 2478374
Disclosed are compounds of the formula I, and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1 , R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
L'invention concerne des composés représentés par la formule (I) ainsi que des sels pharmaceutiquement acceptables et des promédicaments de ces derniers, où W, R?1¿, R?2¿, R?7¿, R?8¿, R?9¿ and R?10¿ sont tels que définis dans le descriptif. De tels composés sont des inhibiteurs de MEK et sont utiles au traitement de maladies hyperprolifératives, telles que le cancer et les inflammations, chez les mammifères. L'invention se rapporte également à un procédé d'utilisation de tels composés dans le traitement de maladies hyperprolifératives chez les mammifères, et à des compositions pharmaceutiques contenant de tels composés.
Hurley T. Brian
Lyssikatos Joseph P.
Marlow Allison L.
Wallace Eli M.
Array Biopharma Inc.
Gowling Lafleur Henderson Llp
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