N3 alkylated benzimidazole derivatives as mek inhibitors

Details N3 alkylated benzimidazole derivatives as mek inhibitors N3 alkylated benzimidazole derivatives as mek inhibitors

A - Human Necessities

61

K

A61K 31/4184 (2006.01) C07D 235/08 (2006.01)

Patent

CA 2537098

Disclosed are compounds of the formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1, R2, R7, R8, R9, and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.

Cette invention concerne des composés représentés par la formule (I) ainsi que des sels et des promédicaments pharmaceutiquement acceptables de ces composés. Dans cette formule, W, R?1¿, R?2¿, R?7¿, R?8¿, R?9¿ et R?10¿ sont tels que définis dans la description. Ces composés sont des inhibiteurs de MEK et servent au traitement de maladies hyperprolifératives, telles que le cancer et l'inflammation, chez les mammifères. Cette invention concerne en outre un procédé d'utilisation de ces composés dans le traitement de maladies hyperprolifératives chez les mammifères ainsi que des compositions pharmaceutiques contenant ces composés.

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