N6-substituted 9-methyladenines: a new class of adenosine...

Details N6-substituted 9-methyladenines: a new class of adenosine... N6-substituted 9-methyladenines: a new class of adenosine...

C - Chemistry, Metallurgy

07

D

167/220, 260/242

C07D 473/34 (2006.01) A61K 31/52 (2006.01)

Patent

CA 1340361

A series of 15 N6-substituted 9-methyladenines have been assessed as antagonists of A2-adenosine receptor-mediated stimulation of adenylate cyclase in membranes of human platelets and rat PC12 cells and of A1-adenosine receptor-mediated inhibition of adenylate cyclases in membranes of rat fat cells and as inhibitors of binding of N6-R-[3H]-phenylisopropyladenosine to A1 adenosine receptors in rat brain membranes.

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