N6-substituted-adenosine-5'-uronamides as adenosine receptor...

Details N6-substituted-adenosine-5'-uronamides as adenosine receptor... N6-substituted-adenosine-5'-uronamides as adenosine receptor...

C - Chemistry, Metallurgy

07

H

C07H 19/16 (2006.01) A61K 31/7076 (2006.01)

Patent

CA 2296485

A series of adenosine-5'-uronamide derivatives bearing N6-arylurea, alkarylurea, heteroarylurea, arylcarbonyl, alkarylcarbonyl or heteroarylcarbonyl groups which have affinity and, in some cases, selectivity for the adenosine A1 or A3 receptors are disclosed. These compounds can be used in a pharmaceutical composition to treat disorders caused by excessive activation of the A1 or A3 receptors, or can be used in a diagnostic application to determine the relative binding of other compounds to the A1 or A3 receptors.

L'invention concerne une série de dérivés d'adénosine-5'-uronamides portant des groupes N?6¿-arylurée, alcarylurée, hétéroarylurée, arylcarbonyle, alcarylcarbonyle ou hétéroarylcarbonyle qui possèdent une affinité, et, dans certains cas, une sélectivité pour les récepteurs A¿1? ou A¿3? d'adénosine. Ces composés peuvent être utilisés dans une composition pharmaceutique pour traiter des troubles provoqués par une activation excessive des récepteurs A¿1? ou A¿3?, ou dans une application diagnostique pour déterminer la fixation d'autres composés aux récepteurs A¿1? ou A¿3?.

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