Na+/k+-atpase-specific peptide inhibitors/activators of src...

Details Na+/k+-atpase-specific peptide inhibitors/activators of src... Na+/k+-atpase-specific peptide inhibitors/activators of src...

C - Chemistry, Metallurgy

12

N

C12N 9/14 (2006.01) A61K 31/17 (2006.01) A61K 38/17 (2006.01) A61K 38/45 (2006.01) A61K 45/00 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 9/99 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) C07H 21/04 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2667251

A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific.

L'invention concerne un procédé destiné à réguler la protéine Src et sa voie de signalisation en aval, qui comprend une liaison entre Src et Na+/K+-ATPase. Le complexe Na+/K+-ATPase/Src est un récepteur fonctionnel pour les stéroïdes cardiotoniques tels que l'ouabaïne. L'invention concerne également des inhibiteurs ou des activateurs de Src, qui comprennent soit Na+/K+-ATPase soit Src et qui interfèrent avec l'interaction entre Na/K-ATPase et Src, agissent via un mécanisme différent de celui des analogues de l'ATP, et sont spécifiques à la voie (Na+/K+-ATPase).

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