C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2527905
Human NADK genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of NADK are provided.
Cette invention se rapporte aux gènes NADK qui sont identifiés comme des modulateurs de la morphogenèse de ramification et qui constituent par conséquent des agents thérapeutiques contre les troubles associés à un dysfonctionnement de la morphogenèse de ramification. Des procédés pour identifier des modulateurs de la morphogenèse de ramification, qui consistent à effectuer le criblage des agents qui modulent d'activité du gène NADK, sont décrits.
Bjerke Lynn Margaret
Habeck Hinrich Alexander
Heuer Timothy S.
Jin Yisheng
Karim Felix D.
Bennett Jones Llp
Exelixis Inc.
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