A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/70 (2006.01) A01N 35/00 (2006.01) A61F 13/00 (2006.01) A61K 31/4174 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2400178
A composition comprising a pharmaceutical compound, a membrane-permeation enhancer, and a polymeric film-forming agent, including, for example, a hydrocarbon-based liquid nail lacquer comprising a solution of an anti-fungal agent in a pharmaceutically-effective amount, a membrane-compatible permeation enhancer in an amount effective to enhance penetration through a membrane or nail of said anti-fungal agent, a polymeric film-forming agent in an amount effective to form an adherent polymeric film on a membrane or nail, and a solvent for forming said solution; and a method for forming on a membrane or nail of the body an adherent film containing a pharmaceutical compound and permeation enhancer from a solution of the components in which there is used a mixture of solvents, including a solvent which is highly volatile and a solvent of lower volatility.
La présente invention concerne une composition pharmaceutique comprenant un composé pharmaceutique, un amplificateur de perméation de membrane, un agent de formation de film polymère, incluant, par exemple, un vernis à ongle liquide à base d'hydrocarbure qui comprend une solution d'un agent antifongique en quantité pharmaceutiquement efficace, un amplificateur de perméation compatible avec la membrane en quantité efficace pour améliorer la pénétration de cet agent antifongique à travers une membrane ou un ongle, un agent de formation de film en quantité efficace pour former un film polymère adhérant sur une membrane ou sur un ongle, et un solvant destiné à former cette solution. Cette invention concerne aussi un procédé permettant de former sur une membrane ou sur un ongle du corps un film adhérant contenant un composé pharmaceutique et un amplificateur de perméation à partir d'une solution de ces composants dans laquelle on utilise un mélange de solvants, notamment un solvant hautement volatil et un solvant d'une volatilité moindre.
Bentley Pharmaceuticals Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cpex Pharmaceuticals Inc.
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