C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 489/08 (2006.01) A61K 31/485 (2006.01) A61P 25/30 (2006.01)
Patent
CA 2722246
The present invention relates to ester prodrugs of nalmefene of formula (I), pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of substance abuse disorders such as alcohol abuse and alcohol dependence and impulse control disorders such as pathological gambling and addiction to shopping.
La présente invention concerne des promédicaments ester de nalméfène de formule (I), des compositions pharmaceutiques comprenant ces composés, et des procédés chimiques de préparation de ces composés. Linvention porte également sur leur utilisation dans le traitement de troubles dus à labus de substance, tels que labus dalcool et la dépendance à lalcool, et de troubles du contrôle de limpulsion, tels que le jeu pathologique et la dépendance aux achats.
Gaekens Tim
Guillaume Michel Joseph Maurice Andre
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica Nv
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