Nano-grid micro reactor and methods

Details Nano-grid micro reactor and methods Nano-grid micro reactor and methods

C - Chemistry, Metallurgy

12

M

C12M 1/34 (2006.01) B01J 19/00 (2006.01) B01L 3/00 (2006.01) B81B 1/00 (2006.01) C12Q 1/24 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2365114

The invention provides exemplary devices and methods to facilitate the performance of assays. In one embodiment, one such device comprises a holding member (58) having a top surface, a bottom surface, and a plurality of holding locations (62) that are adapted to hold at least one article (66), such as a solid support and/or a cell. When within the holding locations, the articles (66) are preferably disposed below the top surface. A membrane (68) is positioned above the top surface of the holding member (58), and a pressure system is provided to apply positive pressure to the membrane (68) to force the membrane (68) against the top surface of the holding member (58). In this way, a seal may be provided between the holding locations (62).

L'invention concerne des dispositifs et des méthodes destinés à augmenter l'efficacité des analyses. Dans un mode de réalisation préféré, un dispositif comprend un élément (58) de support comprenant une surface supérieure, une surface inférieure, et plusieurs emplacements (62) de support adaptés pour servir de support à au moins un article (66), par exemple un support solide et/ou une cellule. Lorsqu'ils se trouvent à l'intérieur des emplacements de support, les articles (66) sont, de préférence, disposés en dessous de la surface supérieure. Une membrane (68) est positionnée au-dessus de la surface supérieure de l'élément (58) de support, et un système de pression sert à exercer une pression positive sur la membrane (68) afin de pousser la membrane (68) contre la surface supérieure de l'élément de support(58). Un joint d'étanchéité peut ainsi être placé entre les emplacements (62) de support.

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